{"id":86,"date":"2020-05-25T19:24:00","date_gmt":"2020-05-25T19:24:00","guid":{"rendered":"http:\/\/www.drchetnacosmeticsurgery.com\/blog\/?p=86"},"modified":"2023-07-13T10:27:45","modified_gmt":"2023-07-13T10:27:45","slug":"use-of-tranexemic-acidtxa-in-treatment-of-melasma","status":"publish","type":"post","link":"https:\/\/www.drchetnacosmeticsurgery.com\/blog\/use-of-tranexemic-acidtxa-in-treatment-of-melasma\/","title":{"rendered":"Use Of Tranexemic Acid(TXA) in treatment of Melasma"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Hi guys this article is about use and efficacy of Tranexemic acid(TXA) in the treatment of Melasma. As I have discussed in my earlier blogs, Melasma<\/strong><\/a> is a skin condition where one gets brown batches on the skin(mainly face) like on bridge of nose, forehead, upper lip and chin. Women of reproductive age that is (30-45 years) are mostly affected, but in 10% of cases it also affects men. <\/p>\n\n\n\n

The precipitating factors for this condition are sun(UV rays) exposure, pregnancy, oral contraceptive pills, hormonal imbalance, genetic predilection(like if your mother, grand mother or any of the aunts had it). This condition adversely affects the looks and the main concern is esthetics, because it is otherwise harmless(pathologically). Once it occurs it is very resistant to all the treatments and also the recurrence rate is quite high, that\u2019s why its very frustrating for both the patient as well as the treating doctor.<\/p>\n\n\n\n

Let me\njust briefly tell you what changes occur in the skin in melasma at the\nmolecular level. Now there are a particular type of cells in the skin called as\nmelanocytes which give colour to the skin, thus the larger number of\nmelanocytes present in the skin, the darker the individual gets. In melasma\nthere is an uncontrolled production of melanocytes in the skin, in the areas of\ndiscolouration.<\/p>\n\n\n\n

 There are various modalities of treatments\nincluding certain topical creams, which are a combination of three creams\nnamely Hydroquinone, Tretinoin and Mometasone. Basically these creams are\nbleaching agents. Other modalities of treatment include chemical peels like glycolic\nacid, kojic acid etc. Then there are lasers like ND-YAG laser, fraxel laser and\nIPL(intense pulse light). Most of these treatments show temporary improvement\nin the condition but there is high recurrence rate and also there are side\neffects like redness, irritation, post inflammatory hyperpigmentation(specially\nwith lasers),that\u2019s why in my clinic I don\u2019t prefer these methods of\ntreatments.<\/p>\n\n\n\n

In my\nexperience and a lot of studies have been done to back it, two method of\ntreatments which have proven to give permanent results in treatment of Melasma\nare PRP(platelet rich plasma) therapy and use of Tranexemic acid. Now I have\nalready discussed about use of PRP for melasma in my earlier blog, so I will\ndiscuss about the Tranexemic acid(TXA).<\/p>\n\n\n\n

Tranexemic\nAcid is a fibrinolytic agent. To explain it in simpler terms, understand this,\nwhen bleeding occurs in our body, after 2-4 minutes, the bleeding stops, why?\nBecause of the formation of blood clot. Our body makes a blood clot which stops\nthe blood flow and bleeding stops. Tranexemic acid plays a role in making blood\nclot more stable and stronger and stops some chemicals(plasmin) in our body\nwhich can cause this blood clot to dissolve. So, basically TXA helps in\nstopping bleeding and that\u2019s why it has been used for years in controlling\nheavy bleeding during menstruation in women, in surgeries to prevent excessive\nbleeding, after child birth to prevent excessive bleeding. <\/p>\n\n\n\n

But\nrecently it was discovered accidently that TXA was also seen to improve Melasma\nand then a lot of studies were done to prove it. It happens because when our\nskin is exposed to UV rays or undergo hormonal changes like in pregnancy or\nother above mentioned conditions there is an increased production of plasmin(\nthe chemical which is responsible for breaking the clots), this plasmin\nincreases the rate of melanogenesis and increased production of melanin and\nhence causes melasma. Now TXA is already known to prevent the formation of\nplasmin. So when it is given in patients having Melasma, it helps in reduction\nof the rate of melanogenesis and thus reduces melanin production and improves Melasma.<\/p>\n\n\n\n

Now lets discuss the methods by which TXA can be given to the patients. First is oral formulation in a dose of 250mg\/ BD, then are though topical creams , and lastly intralesional with the help of mironeedling or mesotherapy. Given in these forms, it has shown a drastic improvement in Melasma.<\/p>\n\n\n

\n
\"\"
TXA given with the help of micronnedling<\/figcaption><\/figure><\/div>\n\n
\n
\"\"
TXA given with the help of mesotherapy<\/figcaption><\/figure><\/div>\n\n\n

In C&S clinic I generally prefer a combination of treatment with PRP and TXA(Tranexemic acid) for Melasma. <\/p>\n\n\n\n

You can\nmail me at drchetnasingh@gmail.com<\/a>\nfor asking your queries and take appointment<\/p>\n","protected":false},"excerpt":{"rendered":"

Hi guys this article is about use and efficacy of Tranexemic acid(TXA) in the treatment of Melasma. As I have discussed in my earlier blogs, Melasma is a skin condition where one gets brown batches on the skin(mainly face) like on bridge of nose, forehead, upper lip and chin. Women of reproductive age that is (30-45 years) are mostly affected, but in 10% of cases it also affects men.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[21],"tags":[23,22],"yoast_head":"\nUse Of Tranexemic Acid(TXA) in treatment of Melasma<\/title>\n<meta name=\"description\" content=\"Hi guys this article is about use and efficacy of Tranexemic acid(TXA) in the treatment of Melasma. 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